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Duff has won just the one cap as a substitute since returning from injury and that came in the friendly against Scotland in August. It took his total of full international caps to 21.
Paterson, who would have had his first international goal last month but for a wrong decision, has won four caps this season to take his total to six having won two as a substitute during his time with Scunthorpe.
It is Northern Ireland's last international of the year before their World Cup campaign resumes in February with their qualifying away game against San Marino.
The full squad for this friendly is: Maik Taylor (Birmingham), Alan Mannus (Linfield), Jonathan Tuffey (Partick Thistle), Chris Baird (Fulham), Gareth McAuley (Ipswich), Jonny Evans (Manchester United), George McCartney (RK Sunderland), Aaron Hughes (Fulham), Michael Duff (Burnley), Ryan McGivern (Manchester City, currently on loan at Morecambe), Steven Davis (Rangers), Michael O'Connor (Crewe), Dean Shiels (Hibs), Keith Gillespie (Sheffield United), Grant McCann (Scunthorpe), Chris Brunt (West Brom), Niall McGinn (Derry), Sammy Clingan (Norwich), David Healy (RK Sunderland), Warren Feeney (Cardiff currently on loan at Dundee United), Kyle Lafferty (Rangers), Peter Thompson (Stockport), Martin Paterson (Burnley).